Description

Introduction

MEGAPEN is a combination antibiotic containing Ampicillin and Cloxacillin, both belonging to the penicillin class of antibiotics. Together, they work by blocking the formation of bacterial cell walls, leading to the destruction of susceptible bacteria. This combination provides broad-spectrum coverage against both gram-positive and some gram-negative bacteria, especially those producing beta-lactamase enzymes.

MEGAPEN is used only for bacterial infections and will not be effective for viral illnesses such as the common cold or flu.

Why MEGAPEN Is Used

Doctors prescribe MEGAPEN when a bacterial infection is suspected or confirmed, particularly when bacteria may produce enzymes that make single antibiotics less effective. It is chosen because it:

• Combines two antibiotics for wider bacterial coverage
• Helps overcome penicillin resistance caused by beta-lactamase–producing bacteria
• Works well for skin, respiratory, and soft tissue infections
• Is effective for mixed bacterial infections

Health Conditions Treated by MEGAPEN

Respiratory Tract Infections

• Pharyngitis
• Tonsillitis
• Bronchitis
• Pneumonia (mild to moderate bacterial cases)

Ear, Nose & Throat Infections

• Otitis media (middle ear infection)
• Sinusitis
• Throat infections

Skin & Soft Tissue Infections

• Cellulitis
• Impetigo
• Wound infections
• Boils and abscesses
• Infected dermatitis

Bone & Joint Infections (as prescribed)

• Osteomyelitis
• Septic arthritis

Urinary Tract Infections

• Uncomplicated bacterial UTIs

Other Infections

• Dental infections
• Bacterial infections caused by penicillin-sensitive organisms

Symptoms Relieved by MEGAPEN

By treating the infection, MEGAPEN helps reduce:

• Fever
• Sore throat
• Ear pain
• Skin redness/swelling
• Pain or pus in infected areas
• Cough with mucus (bacterial)
• Burning or painful urination
• Fatigue due to infection

Side Effects of MEGAPEN (Ampicillin / Cloxacillin)

Common Side Effects

• Nausea
• Vomiting
• Diarrhea
• Abdominal discomfort
• Rash
• Headache

Less Common but Serious Side Effects

Seek immediate medical attention for:

• Severe allergic reactions (swelling, breathing difficulty, hives)
• Persistent diarrhea (possible C. difficile infection)
• Unusual bruising or bleeding
• Severe skin rashes
• Liver-related symptoms (yellowing of skin or eyes)

Diagnosis and When MEGAPEN Is Prescribed

A healthcare provider may prescribe MEGAPEN based on:

Clinical Assessment

• Symptoms
• Physical examination
• Past infection history

Diagnostic Tests (when needed)

• Throat swabs
• Blood tests
• Wound or pus culture
• Urine tests
• Imaging (X-ray/ultrasound for complications)

MEGAPEN is prescribed only when a bacterial infection is likely, helping prevent antibiotic misuse and resistance.

How to Use MEGAPEN Safely

• Take exactly as prescribed
• Do not stop early even if symptoms improve
• Take on an empty stomach (1 hour before or 2 hours after food) for better absorption
• Do not skip doses
• Drink plenty of water
• Avoid self-medication

Important Safety Considerations

Inform your doctor if you have:

• Allergy to penicillins or cephalosporins
• Kidney or liver disease
• Asthma or allergy history
• Gastrointestinal issues

Prevention & Management Tips

• Do not use antibiotics for viral illnesses
• Maintain good hydration
• Rest adequately
• Avoid alcohol if it increases stomach upset
• Do not share antibiotics with others
• Store at room temperature away from moisture

Common Questions About MEGAPEN

How long does it take to work?

Most patients feel improvement within 48–72 hours, but the full course should be completed.

Can children take MEGAPEN?

Yes, but only in doses specified by a doctor—often available in pediatric suspension form.

Is MEGAPEN safe during pregnancy?

Generally considered safe, but always follow your doctor’s advice.

What if I miss a dose?

Take it when you remember, unless it’s close to the next dose. Do not double the dose.

Can MEGAPEN treat dental infections?

Yes, it is commonly used for bacterial dental infections upon dentist recommendation.

Conclusion

MEGAPEN (Ampicillin/Cloxacillin) is an effective combination antibiotic for a wide range of bacterial infections, especially of the skin, respiratory system, and soft tissues. It should be used only under medical supervision. Completing the full course and monitoring for side effects ensures safe and effective treatment.